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14:30 - 18:30 Registration
 
17:00 - 17:30 Opening Ceremony
 
17:30 - 18:30 Opening Lecture
Kyriacos Costa Nicolaous

TOTAL SYNTHESIS OF BIOLOGICALLY ACTIVE MOLECULES
 
18:30 - 19:15 Musajo Award
 
19:15 - 20:00 Farmindustria Awards
 
20:30 - 21:30  WELCOME COCKTAIL
 
08:00 - 09:00 Registration
 
09:00 - 09:45 PL1
Fabrizio Micheli

NEW DEVELOPABLE TEMPLATES AS DOPAMINE D3 ANTAGONISTS
 
09:45 - 10:15 ML1
M. Laura Bolognesi

DESIGN OF BIFUNCTIONAL SMALL MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS IN PRION DISEASES
 
10:15 - 10:45 ML2
Orazio Prezzavento

NOVEL SIGMA RECEPTOR LIGANDS AS NEUROPROTECTIVE AGENTS
 
10:45 - 11:15  Coffee Break
 
11:15 - 11:45 ML3
Paul Smith

NEUROKININ NK3 RECEPTOR ANTAGONISTS WITH CNS ACTIVITY
 
11:45 - 12:45 Short Communications
 
11:45 - 12:00 A. Carocci

Small molecules as MT1 and MT2 ligands: Antioxidant Properties and in vitro inhibition of Ca2+/Cam-dependent Kinase II
 
12:00 - 12:15 C. Mugnaini

Modulation of the physicochemical profile of a set of potent and selective CB2 ligands through a bioisosteric approach
 
12:15 - 12:30 F. Piscitelli

Aminothienopyridazine inhibitors of TAU aggregation
 
12:30 - 12:45 G. Vistoli

The strategy of the conformational chimeras to model the GPCR flexibility: the fertile case of mGluR5 allosteric modulators
 
12:45 - 15:00  Lunch and Poster Session
 
15:00 - 15:45 PL2
Minoru Yoshida

CHEMICAL EPIGENETICS FOR TARGETING CHROMATIN FUNCTION
 
15:45 - 16:15 ML4
Manfred Jung

CHEMICAL EPIGENETICS. PROBING THE BOOKMARKS OF LIFE
 
16:15 - 16:45 ML5
Andrea Mattevi

MONOAMINE OXIDASES AND LSD1: SIMILAR MEDICINAL CHEMISTRY FOR NEUROTRANSMITTER AND CHROMATIN MODIFICATION
 
16:45 - 17:15  Coffee Break
 
17:15 - 17:45 ML6
Dante Rotili

DEVELOPMENT OF CAPTURE COMPOUNDS AS CHEMICAL PROBES FOR 2-OXOGLUTARATE-DEPENDENT OXYGENASES
 
17:45 - 18:15 ML7
Thomas Miller

ZOLINZA AND NEXT-GENERATION HISTONE DEACETYLASE (HDAC) INHIBITORS
 
18:15 - 20:00 ASSEMBLEA DIVISIONE
 
09:00 - 09:45 PL3
Giulio Draetta

CURRENT CHALLENGES IN ONCOLOGY DRUG DISCOVERY AND CLINICAL DEVELOPMENT
 
09:45 - 10:15 ML8
Romano Silvestri

DEVELOPMENT OF NEW TUBULIN TARGETING AGENTS
 
10:15 - 10:45 ML9
Monica Binaschi

ANTI-PROLIFERATIVE AND DIFFERENTIATING ACTIVITIES OF A NOVEL SERIES OF HISTONE DEACETYLASE INHIBITORS
 
10:45 - 11:15  Coffee Break
 
11:15 - 12:45 SCIENCE MEETS BUSINESS - Company presentations
Chairperson: Giuseppe A.M. Giardina
 
11:15 - 11:30 Axxam - Chiara Liberati
 
11:30 - 11:45 Alchemy - Elisabetta Passone
 
11:45 - 12:00 NiKem Research - Giulio Massimo Dondio
 
12:00 - 12:15 UFPeptides - Remo Guerrini
 
12:15 - 12:30 BioIndustryPark Canavese - Fabrizio Conicella
 
12:30 - 12:45 Toscana Life Sciences - Germano Carganico
 
13:00 - 15:00  Lunch and Poster Session
 
15:00 - 15:45 PL4
Stephen Neidle

QUADRUPLEX NUCLEIC ACIDS AS NOVEL ANTICANCER TARGETS
 
15:45 - 16:15 ML10
Gabriella Brasca

DEVELOPMENT OF PYRAZOLO-QUINAZOLINES AS CDK INHIBITORS: IDENTIFICATION OF PHA-848125, A POTENT, ORALLY AVAILABLE COMPOUND
 
16:15 - 16:45 ML11
Matteo Colombo

INDENO-PYRAZINE-DICARBONITRILE DERIVATIVES AS INHIBITORS OF DEUBIQUITINATING ENZYMES
 
16:45 - 17:15  Coffee Break
 
17:15 - 18:45 Short Communications
 
17:15 - 17:30 L.E. Xodo

Control of HRAS transcription and rational design of G4-decoys for cancer therapy
 
17:30 - 17:45 S. Alcaro

Molecular recognition of DNA G-quadruplex ligands by different docking methods
 
17:45 - 18:00 C. Musetti

Design of heterocyclic dications to target biologically relevant quadruplex DNA structures
 
18:00 - 18:15 A. Montalbano

Synthesis and antitumor activity of 3-[2-phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles
 
18:15 - 18:30 M. P. Costi

Tethering low affinity ligands to the dimeric interface of human thymidylate synthase
 
18:30 - 18:45 R. Bertani

New antitumor chemicals from Platinum(II)-nitrile complexes
 
19:30 - 21:00 CONCERT
 
09:00 - 09:45 PL5
Giorgio Palù

NOVEL ANTIVIRAL AGENTS: WHERE ARE WE GOING?
 
09:45 - 10:15 ML12
Mark R. Sanderson

STRUCTURAL STUDIES ON THE QUINOLONE CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES
 
10:15 - 10:45 ML13
Oriana Tabarrini

HIV-1 TRANSCRIPTION INHIBITORS FOR AN INNOVATIVE CHEMOTHERAPEUTIC INTERVENTION
 
10:45 - 11:15  Coffee Break
 
11:15 - 12:15 Short Communications
 
11:15 - 11:30 A. Obreza

The design and synthesis of new low-molecular-weight inhibitors of Mur-ligases
 
11:30 - 11:45 G. Poce

Identification of a new chemical class of potent antimycobacterial compounds
 
11:45 - 12:00 S. Romeo

Design and synthesis of protein-protein interaction mimics as inhibitors of Plasmodium Falciparum cysteine protease Falcipain-2
 
12:00 - 12:15 S. Comai

Study of tryptophan metabolism in patients with chronic hepatitis C treated with PEG-interferon alpha plus ribavirin
 
12:15 - 13:00 Poster Session
 
13:00 - 15:00  Lunch
 
15:00 - 15:45 PL6
Helena Danielson

INTERACTION ANALYSIS FOR LEAD DISCOVERY AND OPTIMIZATION
 
15:45 - 16:15 ML14
Serge Rudaz

NEW INSIGHTS IN CAPILLARY ELECTROPHORESIS FOR THE ANALYSIS OF PHARMACEUTICAL COMPOUNDS
 
16:15 - 16:45 ML15
Luigi Colombo

NEW ANALYTICAL TECHNOLOGIES: PHARMACEUTICAL APPLICATIONS TO PROTEINS AND ANTIBODIES. AN INDUSTRY PERSPECTIVE
 
16:45 - 17:00  Coffee Break
 
17:00 - 18:00 Short Communications
 
17:00 - 17:15 E. De Lorenzi

Capillary electrophoresis, mass spectrometry and in silico studies: a multidisciplinary approach for drug discovery
 
17:15 - 17:30 G. Aldini

The discovery of Carnosine derivatives as selective and efficient sequestering agents of cytotoxic carbonyl species: from molecular design to preclinical studies”
 
17:30 - 17:45 E. Calleri

Development and application of chromatographic tools based on immobilized PPAR-gamma receptor for binding studies
 
17:45 - 18:00 M. Bartolini

A multi-methodological approach for Beta-amyloid aggregation and inhibition studies
 
18:00 - 18:15 R. Mandrioli

Screening and confirmation of suspected benzodiazepine abuse: TLC and HPLC analysis in urine
 
20:00 - 23:30  CONFERENCE DINNER (location tbc)
 
09:00 - 09:45 PL7
Maurizio Botta

MULTIPLE TARGETS TO SWITCH OFF THE HIV LIFE CYCLE
 
09:45 - 10:15 ML16
Luciana Marinelli

TARGETING DNA G QUADRUPLEX THROUGH IN SILICO DRUG DISCOVERY METHODS
 
10:15 - 10:45 ML17
Rosella Ombrato

ELUCIDATION OF THE THREE-DIMENSIONAL STRUCTURE OF MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 THROUGH HOMOLOGY MODELING
 
10:45 - 11:15  Coffee Break
 
11:15 - 12:30 Short Communications
 
11:15 - 11:30 A. Bassan

Large-scale systematic analysis of 2D fingerprint methods and parameters to improve virtual screening enrichments
 
11:30 - 11:45 A. Lodola

Chemical determinants of Fatty acid amide hydrolase inactivation explored by QM/MM mechanistic modelling”.
 
11:45 - 12:00 G. Rastelli

Improving enrichment and hit rates in virtual screening“.
 
12:00 - 12:15 A. Cristiani

A new web available bio-molecule MD simulator: ClickMD!
 
12:15 - 12:30 G. Bottegoni

Computational exploration of the kinome space: have we really seen it all?
 
12:30 - 12:45 Closing Ceremony
 

Opening Lecture -> 60 minutes
Plenary Lectures (PL) -> 45 minutes
Main Lectures (ML) -> 30 minutes
Short Communications -> 15 minutes

 
 
 
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